Peer Reviewed Publications: Research Investigations

Nizamuddin J, Gupta A, Patel V, Minhaj M, Nizamuddin SL, Mueller AL, Naseem H, Tung A, Rana S, Shahul S. Hypertensive Diseases of Pregnancy Increase Risk of Readmission With Heart Failure: A National Readmissions Database Study. Mayo Clin Proc. 2018 Dec 18. PMID:30601575

Minhas R, Young D, Naseem R, Mueller A, Chinthala S, Perdigao JL, Yeo KJ, Chan SL, Tung A, White JB, Shahul S, Rana S. Association of antepartum blood pressure levels and angiogenic profile among women with chronic hypertension. Pregnancy Hypertens. 2018 Oct;14:110-114. PMID:30527096

Rana S, Salahuddin S, Mueller A, Berg AH, Thadhani RI, Karumanchi SA. Angiogenic biomarkers in triage and risk for preeclampsia with severe features. Pregnancy Hypertens. 2018 Jul;13:100-106. PMID:30177034

Sajid Shahul, Hadi Ramadan, Junaid Nizamuddin, Ariel Mueller, Vijal Patel, John Dreixler,
Avery Tung, Roberto M. Lang, Lynn Weinert, Rabab Nasim, Sireesha Chinthala, Sarosh Rana. Activin A and Late Postpartum Cardiac Dysfunction Among Women With Hypertensive Disorders of Pregnancy Hypertension. 2018 Jul;72(1):188-193

Pels A, Mol BWJ, Singer J, Lee T, von Dadelszen P, Ganzevoort W, Asztalos E, Magee LA; CHIPS Study Group. Influence of Gestational Age at Initiation of Antihypertensive Therapy: Secondary Analysis of CHIPS Trial Data (Control of Hypertension in Pregnancy Study). Hypertension. 2018 Jun;71(6):1170-1177.

Chan SL, Rana S, Chinthala S, Salahuddin S, Yeo KJ. Analytical validation of soluble fms-like tyrosine and placental growth factor assays on B·R·A·H·M·S KRYPTOR Compact Plus automated immunoassay platform. Pregnancy Hypertens. 2018 Jan;11:66-70

Chhabra N, Gupta A, Chibber R, Minhaj M, Hofer J, Mueller A, Tung A, O'Connor M, Scavone B, Rana S, Shahul S. Outcomes and mortality in parturient and non-parturient patients with peripartum cardiomyopathy: A national readmission database study. Pregnancy Hypertens. 2017 Oct;10:143-148. doi: 10.1016/j.preghy.2017.07.147. Epub 2017 Jul 25.

Kang E, Sugarman R, Ramadan H, Mueller A, Shahul S, Perdigao JL, Louis DJ, Narcisse R, Sannon H, Magee L, Rana S.Prevalence, risk factors and associated complications of postpartum hypertension in rural Haiti. Pregnancy Hypertens. 2017 Oct;10:135-142. doi: 10.1016/j.preghy.2017.07.143. Epub 2017 Jul 25. PMID: 29153666

Dutta A, Khramtsova G, Brito K, Alexander D, Mueller A, Chinthala S, Adu D, Ibigbami T, Olamijulo J, Odetunde A, Adigun K, Pruitt L, Hurley I, Olopade O, Ojengbede O, Rana S, Olopade CO. Household air pollution and chronic hypoxia in the placenta of pregnant Nigerian women: A randomized controlled ethanol Cookstove intervention. Sci Total Environ. 2017 Nov 14;619-620:212-220. doi: 10.1016/j.scitotenv.2017.11.091. [Epub ahead of print] PMID: 29149745 

Shahul S, Ramadan H, Mueller A, Nizamuddin J, Nasim R, Lopes Perdigao J, Chinthala S, Tung A, Rana S. Abnormal mid-trimester cardiac strain in women with chronic hypertension predates superimposed preeclampsia. Pregnancy Hypertens. 2017 Oct;10:251-255. doi: 10.1016/j.preghy.2017.10.009. Epub 2017 Oct 23. PMID: 29111424

Ramadan H, Rana S, Mueller A, Bajracharya S, Zhang D, Salahuddin S, Nasim R, Perdigao JL, Minhaj M, Tung A, Arany Z, Shahul S. Myocardial performance index in hypertensive disorders of pregnancy: The relationship between blood pressures and angiogenic factors. Hypertens Pregnancy. 2017 May;36(2):161-167.

Dutta A, Brito K, Khramstova G, Mueller A, Chinthala S, Alexander D, Adu D, Ibigbami T, Olamijulo J, Odetunde A, Adigun K, Pruitt L, Olopade O, Ojengbede O, Rana S, Olopade CO. Household air pollution and angiogenic factors in pregnant Nigerian women: A randomized controlled ethanol cookstove intervention. Sci Total Environ. 2017 Dec 1;599-600:2175-2181

Rana S, Sannon H. Angiogenic Proteins: Can These Biomarkers Help to Prevent Maternal Deaths Related to Preeclampsia? Hypertension. 2017 Mar;69(3):401-403

Siddiqui M, Minhaj M, Mueller A, Tung A, Scavone B, Rana S, Shahul S.Increased Perinatal Morbidity and Mortality Among Asian American and Pacific Islander Women in the United States. Anesth Analg. 2017 Jan 17

Nadkarni NA, Rajakumar A, Mokhashi N, Burke SD, Rana S, Salahuddin S, Dang Q, Thadhani R, Krishnan R, Stossel TP, Karumanchi SA. Gelsolin is an endogenous inhibitor of syncytiotrophoblast extracellular vesicle shedding in pregnancy. Pregnancy Hypertens. 2016 Oct;6(4):333-339

Zsengellér ZK, Rajakumar A, Hunter JT, Salahuddin S, Rana S, Stillman IE, Ananth Karumanchi S. Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase 1. Pregnancy Hypertens. 2016 Oct;6(4):313-319

Banayan J, Rana S, Mueller A, Tung A, Ramadan H, Arany Z, Nizamuddin J, Novack V, Scavone B, Brown SM, Shahul S. Cardiogenic shock in pregnancy: Analysis from the National Inpatient Sample. Hypertens Pregnancy. 2016 Nov 11:1-7

Shahul S, Medvedofsky D, Wenger JB, Nizamuddin J, Brown SM, Bajracharya S, Salahuddin S, Thadhani R, Mueller A, Tung A, Lang RM, Arany Z, Talmor D, Karumanchi SA, Rana S Circulating Antiangiogenic Factors and Myocardial Dysfunction in Hypertensive Disorders of Pregnancy. Hypertension. 2016 Jun;67(6):1273-80

Salahuddin S, Wenger JB, Zhang D, Thadhani R, Karumanchi SA, Rana S. KRYPTOR-automated angiogenic factor assays and risk of preeclampsia-related adverse outcomes. Hypertens Pregnancy. 2016 Aug;35(3):330-45

Baltajian K, Bajracharya S, Salahuddin S, Berg AH, Geahchan C, Wenger JB, Thadhani R, Karumanchi SA, Rana S. Sequential plasma angiogenic factors levels in women with suspected preeclampsia. Am J Obstet Gynecol. 2016 Jul;215(1):89.e1-89.e10.

Shahul S, Tung A, Minhaj M, Nizamuddin J, Wenger J, Mahmood E, Mueller A, Shaefi S, Scavone B, Kociol RD, Talmor D, Rana S. Racial Disparities in Comorbidities, Complications, and Maternal and Fetal Outcomes in Women With Preeclampsia/eclampsia. Hypertens Pregnancy. 2015 Nov;34(4):506-515

Kim MY, Buyon JP, Guerra MM, Rana S, Zhang D, Laskin CA, Petri M, Lockshin MD, Sammaritano LR, Branch DW, Porter TF, Merrill JT, Stephenson MD, Gao Q, Karumanchi SA, Salmon JE. Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study. Am J Obstet Gynecol. 2016 Jan;214(1):108.e1-108

Goel A, Maski MR, Bajracharya S, Wenger JB, Zhang D, Salahuddin S, Shahul SS, Thadhani R, Seely EW, Karumanchi SA, Rana S. Epidemiology and Mechanisms of De Novo and Persistent Hypertension in the Postpartum Period. Circulation. 2015 Nov 3;132(18):1726-33

March MI, Geahchan C, Wenger J, Raghuraman N, Berg A, Haddow H, Mckeon BA, Narcisse R, David JL, Scott J, Thadhani R, Karumanchi SA, Rana S. Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia. PLoS One. 2015 May 12;10(5):

Palomaki GE, Haddow JE, Haddow HR, Salahuddin S, Geahchan C, Cerdeira AS, Verlohren S, Perschel FH, Horowitz G, Thadhani R, Karumanchi SA, Rana S. Modeling risk for severe adverse outcomes using angiogenic factor measurements in women with suspected preterm preeclampsia. Prenat Diagn 2015 Apr;35(4):386-93.

March MI, Gupta M, Perport Modest A, Wu L, Hacker MR, Martin C, Rana S. Maternal Risk Factors for Neonatal Necrotizing Enterocolitis.  J Matern Fetal Neonatal Med. 2014; 27:1-6.

Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira AS, Burke S, George E, Granger J, Karumanchi SA.Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway. FASEB J. 2014 ;28(10):4324-34.

Raghuraman N, March MI, Hacker MR, Modest AM, Wenger J, Narcisse R, Louis David J, Scott J, Rana S Adverse maternal and fetal outcomes and deaths related to preeclampsia and eclampsia in Haiti. Pregnancy Hypertens. 2014 Oct;4(4):279-86

Cohen AL, Wenger JB, James-Todd T, Lamparello BM, Halprin E, Serdy S, Fan S, Horowitz GL, Lim KH, Rana S, Takoudes TC, Wyckoff JA, Thadhani R, Karumanchi SA, Brown FM The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes Hypertens Pregnanc 2014 Feb;33(1):81-92

Bdolah Y, Elchalal U, Natanson-Yaron S, Yechiam H, Bdolah-Abram T, Greenfield C, Goldman-Wohl D, Milwidsky A, Rana S, Karumanchi SA, Yagel S, Hochner-Celnikier D. Relationship between nulliparity and preeclampsia may be explained by altered circulating soluble fms-like tyrosine kinase 1. Hypertens Pregnancy 2014 May;33(2):250-9

Rana S, Karumanchi S.A, Lindheimer MD. Angiogenic Factors in Diagnosis, Management, and Research in Preeclampsia. Hypertension. 2014; 63(2): 198-202.

Rana S, Schnettler WT, **Powe C, Wenger J, Salahuddin S, Cerdeira AS, Verlohren S, Perschel FH, Arany Z, Lim KH, Thadhani R, Karumanchi SA. Clinical Characterization and Outcomes of Preeclampsia with Normal Angiogenic Profile. Hypertens Pregnancy. 2013; 32(2): 189-201.

Schnettler WT, Dukhovny D, Wenger J, Salahuddin S, Ralston SJ, Rana S. Cost and resource implications with serum angiogenic factor estimation in the triage of preeclampsia. BJOG. 2013; 120(10): 1224-32.

Schaarschmidt W, Rana S, Stepan H. The course of angiogenic factors in early- versus late-onset preeclampsia and HELLP syndrome. J Perinat Med. 2013; 11:1-6.

Lely TA, Salahuddin S, Holwerda KM, Karumanchi SA, Rana S. Circulating Lymphangiogenic Factors in Preeclampsia. Hypertens Pregnancy. 2013; 32(1): 42-9.

Rana S, Cerdeira AS, Wenger J, Salahuddin S, Lim KH, Ralston RJ, Thadhani R, Karumanchi SA. Plasma concentrations of soluble endoglin versus standard evaluation in patients with suspected preeclampsia. PLoS One. 2012; 7(10): e48259.

Shahul S, Rhee J, Hacker MR, Gulati G, Mitchell JD, Hess P, Mahmood F, Arany Z, Rana S, Talmor D. Subclinical Left Ventricular Dysfunction in Preeclamptic Women with Preserved Left Ventricular Ejection Fraction: A 2D Speckle Tracking Imaging Study. Circ Cardiovasc Imaging. 2012; 5(6): 734-9.

Rana S, Hacker MR, Merport Modest A, Salahuddin S, Lim KH, Verlohren S, Perschel FH, Karumanchi SA. Circulating Angiogenic Factors and Risk of Adverse Maternal and Perinatal Outcomes in Twin Pregnancies with Suspected Preeclampsia. Hypertension. 2012; 60(2): 451-8.

Patten IS#, Rana S#, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, **Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, Monte F , Hilfiker-Kleiner D, Karumanchi SA , Arany Z. Cardiac Angiogenic Imbalance Leads to Peri-partum Cardiomyopathy. Nature. 2012; 485: 333–338.  #equal contribution.

Khankin EV, Hacker MR, Zelop CM, Karumanchi SA, Rana S. Intravital high frequency ultrasonography of cardiovascular and uteroplacental blood flow in mouse pregnancy. Pregnancy Hypertens. 2012; 2(2): 84-92.

Schnettler WT, Hacker MR, Barber R, Rana S. Management of abnormal serum markers in the absence of aneuploidy or neural tube defects. J Matern Fetal Neonatal Med. 2012; 25(10): 1895-8

Rana S, Powe CE, Salahuddin S, Verlohren S, Perschel FH, Levine RJ, Lim KH, Wenger JB, Thadhani R, Karumanchi SA. Angiogenic Factors and the Risk of Adverse Outcomes in Women with Suspected Preeclampsia. Circulation. 2012; 125(7): 911-9.

Rajakumar A, Cerdeira AS, Rana S, Zsengeller A, Edmunds L, Jyyabalan A, Hubel CA, Stilmann IE, Parikh SM, Kraumanchi SA. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating sFlt1 in preeclampsia. Hypertension. 2012; 59(2): 256-64

Young B, Hacker M, Rana S. Physician’s knowledge of future vascular disease in women with preeclampsia.Hypertens Pregnancy. 2012; 31(1): 50-8

Vadnais, M, Rana S, Quant H, Salahuddin S, Dodge L, Lim KH, Karumanchi SA, Hacker M. The impact of magnesium sulfate therapy on angiogenic factors in preeclampsia. Pregnancy Hypertens. 2012; 2(1): 16-21

Mijal RS, Holzman CB, Rana S, Karumanchi A, Wang J, Sikorskii A. Midpregnancy levels of angiogenic factors and pathways to preterm delivery. J Matern Fetal Neonatal Med. 2012; 25(7): 1135-41

Poston L, Igosheva N, Mistry HD, Seed PT, Shennan AH, Rana S, Karumanchi SA, Chappell LC. The role of oxidative stress and antioxidant supplementation in pregnancy disorders. Am J Clin Nutr. 2011; 94(6): 1980S-5S

Silasi M, Rana S, Powe CE, Cohen B, Lim KH, Karumanchi SA, Stillman I. Placental expression of angiogenic factors in Trisomy 13. Am J Obstet Gynecol. 2011; 204(6): 546.e1-4.

Powe CE, Ecker J, Rana S, Wang A, Ankers L, Ye J, Levine RJ, Karumanchi SA, Thadhani R . Preeclampsia and the risk of large for gestational age infants. Am J Obstet Gynecol. 2011; 204(5): 425.e1-6.

Mijal RS, Holzman CB, Rana S, Karumanchi SA, Wang J, Sikorskii A. Midpregnancy levels of angiogenic markers in relation to maternal characteristics. Am J Obstet Gynecol. 2011; 204(3): 244.e1-12.

Powe CE, Seely EW, Rana S, Bhan I, Ecker J, Karumanchi SA, Thadhani R. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension. 2010; 56(4): 758-63

Steinberg G, Lee C, Rauh-Hain JA, Ecker J, Khankin EV, Hsu CD, Cohen B, Rana S, Karumanchi SA, Thadhani R, Hacker MR, Lim KH. Early-pregnancy soluble Fas levels in idiopathic small-for-gestational-age pregnancies. Am J Obstet Gynecol. 2010; 202(3): 299. e1-7

Young B, Levine RJ, Salahuddin S, Qian C, Lim KH, Karumanchi SA, Rana S: The use of angiogenic biomarkers to differentiate non-HELLP related thrombocytopenia from HELLP syndrome. J Matern Fetal Neonatal Med. 2010; 23(5): 366-70

Rauh-Hain A, Rana S, Tamez H, Wang A, Cohen B, Cohen A, Brown F,  Ecker JL, Karumanchi SA, Thadhani R: Risk for developing gestational diabetes in women with twin pregnancies. J Matern Fetal Neonatal Med. 2009; 25:1-7

Signore C, Mills JL, Qian C, Yu KF, Rana S, Karumanchi SA, Levine RJ.  Circulating soluble endoglin and placental abruption.  Prenat Diagn. 2008; 28(9): 852-8

Rana S, Karumanchi SA, Levine RJ, Venkatesha S, Rauh-Hain JA, Tamez H, Thadhani R.  Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia.  Hypertension 2007; 50 (1): 137-42

Rana S, Karumanchi SA, Levine RJ, Venkatesha S, Rauh-Hain JA, Tamez H, Thadhani R.  Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia.  Hypertension 2007; 50 (1): 137-42

Cohen A, Lim KH, Lee Y, Rana S, Karumanchi SA, Brown F.  Circulating levels of antiangiogenic marker soluble FMS-like tyrosine kinase1 are elevated in women with pregestational diabetes and preeclampsia:  angiogenic markers in preeclampsia and preexisting diabetes.  Diabetes Care 2007; 30(2): 375-7.

Rana S, Lindheimer M, Hibbard J, Pliskin N.  Neuropsychological performance in normal pregnancy and preeclampsia.  Am J Obstet Gynecol 2006; 195 (1): 186-91

Abramowicz JS, Rana S, Abramowicz S.  Fetal cheek-to-cheek diameter in the prediction of mode of delivery.  Am J Obstet Gynecol 2005; 192 (4): 1205-13

Kumar RM, Uduman S, Rana S, Kochiyil JK, Usmani A, Thomas L.  Sera-prevalence and mother-to infant transmission of Hepatitis E virus among pregnant women in the United Arab Emirates.  Euro J Obstet Gynecol Reprod Biology 2001; 100: 9-15.

Saxena K, Haroon S, Rabbani T, Rana S.  Blood flow studies in evaluation of fetal well being:  a study of normal and abnormal pregnancies.  J Obstet Gynecol lndia 2001; 51:64-72

Peer Reviewed Publications: Case Studies

Quant H, Arden D, Takoudes T, Rana S. Angiogenic factors and pregnant woman with new onset seizures.. Hypertens Pregnancy. 2012; 31(2): 207-10

Bixel K, Silasi M, Zelop CM, Lim KH, Zsengeller Z, Stillman I, Rana S. Placental Origins of Angiogenic Dysfunction in Mirror Syndrome. Hypertens Pregnancy. 2012; 31(2): 211-7

Rhee J, **Young BC, Rana S. Angiogenic Factors and Renal disease in Pregnancy. Case reports in Obstetrics and Gynecology. 2011.

Young B, Takoudes T, Lim KH, Rana S: Rupture of the posterior cul-de-sac during spontaneous labor. Obstet Gynecol. 2010; 115: 414-7

Shan HY, Rana S, Epstein FH, Stillman IE, Karumanchi SA, Williams ME.  Use of circulating antiangiogenic factors to differentiate other hypertensive disorders from preeclampsia in a pregnant woman on dialysis.  Am J Kidney Dis. 2008; 51(6): 1029-32

Rana S, Venkatesha S, DePaepe M, Chien E, Paglia M, Karumanchi SA.  Cytomegalovirus-induced mirror syndrome associated with elevated levels of circulating antiangiogenic factors.  Obstet Gynecol 2007; 109(2Pt2): 549-52.

Rana S, Warren BK, Yamada SD.  Stage IIIC small cell carcinoma of the ovary:  survival with conservative surgery and chemotherapy.  Obstet Gynecol 2004; 103(5 Pt2): 1120-3

Rana S, Stanhope RC, Gaffey T, Morrey BF, Dumesic DA.  Retroperitoneal endometriosis causing unilateral hip pain.  Obstet Gynecol 2001; 98:970-2

Hakim S, Bano I, Bhardwaj NA, Anis A, Rana S.  Dermoid cyst of mons pubis: a case report. J Obstet Gynecol India 2000; 51: 121

Non-peer reviewed scientific publications (Book Chapters/Reviews/Editorials)

Karumanchi SA, Rana S, Robert Taylor. Book Chapter: Angiogenesis and Preeclampsia. Chesley’s hypertensive disorders in pregnancy, Fourth Edition. Elsevier Inc. 2014, Chapter 6

Goel A and Rana S. Angiogenic Factors in Preeclampsia: Potential for Diagnosis and Treatment. Curr Opin Nephrol Hypertens. 2013; 22(6): 643-650

Rana S, Karumanchi SA, Norwitz E. Book Chapter: Screening for hypertensive disorders of pregnancy. Hypertension in Pregnancy, Cambridge University Press. 2010, Chapter 4

Silasi M, Cohen B, Karumanchi SA, Rana, S: Abnormal Placentation, Angiogenic Factors, and the Pathogenesis of Preeclampsia. Obstetrics and Gynecology Clinics of North America 2010; 37(2): 239-253

Maski M, Rana S, Karumanchi SA. Book Chapter: Biomarkers in Obstetric Medicine. Biomarkers in Medicine, Drug Discovery, and Environmental Health, John Wiley and Sons. 2010, Section II, Chapter 13

Tjoa M, Khankin E, Rana S, Karumanchi SA. Book Chapter: Angiogenic and anti-angiogenic factors. Placental Bed Disorders: Basic Science & its translation to obstetrics, Cambridge University Press. 2010, Section 7, Chapter 21

Wang A, Rana S, Karumanchi SA: Preeclampsia. Physiology. 2009; 24:147-58

Rana S, Lindheimer MD, Karumanchi SA.  Angiogenic proteins as markers for predicting preeclampisa.  Expert Review of Obstet Gynecol 2007; 2(1): 61-65

Rana S.  Practical strategies in Obstetrics & Gynecology (book review).  Fertility Sterility 2000,74 (2): 425


Peer Reviewed Publications

Research Investigations

Case Studies

Non-Peer Reviewed Publications (Book Chapters, Reviews, Editorials)