Peer-Reviewed Publications

Romero I, Turok D, Gilliam M Tramadol as an adjunct for pain control during vacuum aspiration abortion. Contraception. 2008 Jan; 77(1):56-9. PMID: 18082668.

Romero IL, Gordon IO, Jagadeeswaran S, Mui KL, Lee WS, Dinulescu DM, Krausz TN, Kim HH, Gilliam ML, and Lengyel E.  Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice. Cancer Prevention Research. 2009 Sept; 2(9):792-99.PMID: 19737983.   

Chen L, Park SM, Tumanov A, Hau A, Sawada K, Feig C, Turner J, Fu YX, Romero IL, Lengyel E, and Peter ME.  CD95 drives tumour growth. Nature. 2010 May 27;465(7297):462-6. PMID: 20505730.

Zillhardt M, Park SM, Romero IL, Sawada K, Montag A, Krausz T, Yamada D, Peter ME, and Lengyel E.  Foretinib (GSK1363089), an orally available multi-kinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.  Clinical Cancer Research. 2011 June 15;17(12):4042-51. PMID 21551255

Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada  SD, Peter ME, Gwin K, and Lengyel E.  Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nature Medicine 2011 October 30;17(11):1149-1503. PMID 22037646

Romero IL, Lee W, Mitra AK, Gordon IO, Zhao Y, Leonhardt P, Penicka CV, Mui KL, Krausz TN, Greene GL, and Lengyel E. The effects of 17β-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis. Gyn Oncology, 2012 Jan;124(1):134-41. PMID 21996264

Romero IL, McCormick A, McEwen KA, Park S, Karrison T, Yamada SD, Pannain S, and Lengyel E. Relationship of type II diabetes and metformin use to ovarian cancer progression, survival and chemosensitivity. Obstet Gynecol. 2012 Jan;119(1):61-7. PMID 22183212.

Nieman K, Romero IL, Van Houten B, Lengyel E. Adipose tissue and adipocytes supports tumorigenesis and metastasis. BBA - Molecular and Cell Biology of Lipids Corresponding. 2013 March [1831:1533-1541. PMID 23500888

Habis M, Wroblewski K, Bradaric M, Ismail N, Litchfield L, Lengyel E, and Romero IL. Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: A retrospective cohort analysis. PLOS One. 2014 Aug 13;9(8):e104521. doi: 10.1371/journal.pone.0104521. eCollection 2014. PMID: 25118694.

Kenny HA, Chiang C, White E, Ladanyi A, Habis M, Romero IL, Schryver EM, Penicka C, George J, Matlin K, Montag A, Yamada D, Mazar A, Bowtell D, and Lengyel L. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. Journal of Clinical Investigation.2014 Oct 1;124(10):4614-28. doi: 10.1172/JCI74778. Epub 2014 Sep 9. PMID: 25202979. 

Lengyel E, Litchfield L, Mitra AK, Nieman KM, Mukherjee A, Johnson A, Bradaric M, Lee W, and Romero IL. Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel. American Journal of Obstetrics and Gynecology.2014 Oct 19. pii: S0002-9378(14)01081-3. doi: 10.1016/j.ajog.2014.10.026. [Epub ahead of print] PMID: 25446664.

Febbrarro T, Lengyel E, and Romero IL. Old drug, new trick: Repurposing metformin for gynecologic cancers? Gynecology Oncology.2014 Dec;135(3):614-621. doi: 10.1016/j.ygyno.2014.10.011. Epub 2014 Oct 23. Review. PMID: 25455733 

Romero IL, Mukherjee A, and Lengyel E. Molecular Pathways: Reciprocal regulation of cancer and stromal cells. Clinical Cancer Research2015 Feb 15;21(4)680-6. PMID 25691772

Lengyel E, Litchfield L, Mitra AK, Nieman KM, Mukherjee A, Johnson A, Bradaric M, Lee W, and Romero IL. Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel. American Journal of Obstetrics and Gynecology.2015 April;212(4):479.e1-479.e10. PMID 25446664

Litchfield LM, Johnson A, Mills KA, Pan S, Shridhar V, Lengyel E, and Romero IL. Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer. Oncotarget. 2015 Sept 15;6(27):23548-60. PMID 26172303

Ozewuiro O, Grushko TA, Kocherginsky M, Habis M, Olopade OI, Hurteau JA, Mills KA, Hunn J, Fleming GF, and Romero IL. Association of metformin use and outcomes in advanced endometrial cancer treated with chemotherapy. PLOS One. Under revision

Bowtell D, Bohm S, Ahmed AA, Romero IL, Scott CL, Sood AK, Stronach EA, Balkwill FR et al. Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer.Nat Rev Cancer. 2015 Oct 23;15(11):668-79. PMID:26493647